By Vikas Bhushan
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USMLE Step 1: evaluation "Blackwell's Underground medical Vignettes (subject, ed. )" is your fundamental resource for clinically correct, case-based fabric crucial for Step 1 evaluation. each one medical Vignette simulates USMLE structure, and comprises vintage buzzwords in Hx, PE, lab, imaging and pathology. This revised variation includes: conscientiously chosen circumstances templated to slot how you are demonstrated and taught to imagine; useful hyperlinks to Step 1 and a pair of Atlases for emphasis on photographic case reviews; and 50+ new instances suitable with the up to date content material of USMLE Step 1 research with the student-to-student writer you could belief!
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Extra resources for Underground Clinical Vignettes: Pharmacology: Classic Clinical Cases for USMLE Step 1 Review
Oligodendrocytes are the myelin-forming cells of the central nervous system (CNS). In the CNS, myelination begins during the fourth month of development and continues into the second decade of life. An individual oligodendrocyte is able to myelinate many axons. Node of Ranvier At the junction between two myelin-producing cells, there is a discontinuity in the myelin. This creates a "collar" of naked axon, called a node of Ranvier, which is exposed to the extracellular space (Figure 1-2-1). The action potential skips from node to node in a process called saltatory conduction.
Smooth endoplasmic reticulum ! (SER) lacks ribosomes. It is involved in detoxification reactions-hydroxylation, via cytochrome I P450, and conjugation. It forms glucose from glycogen via membrane-bound enzyme glucose-6 I phosphatase and lipolysis by releasing fatty acid from triglyceride. Other products made here include ! phospholipids, lipoproteins, and sterols. SER in striated muscle is known as sarcoplasmic reticulum. Calcium ions are sequestered and released here. Rough endoplasmic reticulum (RER) contains I ribosomes that synthesize proteins that are delivered to Golgi apparatus, Iysosomes, and plasma I membrane.
24 KAPLAlfdme leaI . \~< i~; . ~ ":'''' " "! • • •• ' ..... Nervous Tissue NEURONS Neurons are composed of three basic parts: the cell body (soma or perikaryon); the dendrites, which receive information from other neurons; and a single axon, which conducts electrical impulses away from the cell body (Figure 1-2-1). Cell Body The cell body contains a large vesicular nucleus with a single prominent nucleolus, mitochondria, and other organelles. It has abundant RER, reflecting high rates of protein synthesis.