Lecture notes. / Haematology by Chris Hatton, (Hematologist); et al

By Chris Hatton, (Hematologist); et al

Haematology Lecture Notes is an obtainable and concise best-selling learn consultant, outlining the body structure, pathology and remedy of the commonest blood issues. broadly revised and up-to-date to mirror the substantial advances within the knowing of the molecular biology and pathogenesis of haematological issues, it offers the middle wisdom required through all clinical scholars and junior doctors.

Key good points include:

  • New fabric on coagulation and transfusion
  • Expanded assurance of haematopoiesis
  • A whole replace of all malignant haematology content

A fresh significant other web site at www.lecturenoteseries.com/haematology that includes interactive MCQs with suggestions on every one solution chosen, bankruptcy summaries and revision notes in PowerPoint and PDF codecs, and all of the figures from the publication in PowerPoint format

Whether drawing close haematology for the 1st time, or searching for a refresher, Haematology Lecture Notes will let scholars and junior medical professionals to improve an knowing of either the fundamental technological know-how and medical elements of this specialty.

Show description

By Chris Hatton, (Hematologist); et al

Haematology Lecture Notes is an obtainable and concise best-selling learn consultant, outlining the body structure, pathology and remedy of the commonest blood issues. broadly revised and up-to-date to mirror the substantial advances within the knowing of the molecular biology and pathogenesis of haematological issues, it offers the middle wisdom required through all clinical scholars and junior doctors.

Key good points include:

  • New fabric on coagulation and transfusion
  • Expanded assurance of haematopoiesis
  • A whole replace of all malignant haematology content

A fresh significant other web site at www.lecturenoteseries.com/haematology that includes interactive MCQs with suggestions on every one solution chosen, bankruptcy summaries and revision notes in PowerPoint and PDF codecs, and all of the figures from the publication in PowerPoint format

Whether drawing close haematology for the 1st time, or searching for a refresher, Haematology Lecture Notes will let scholars and junior medical professionals to improve an knowing of either the fundamental technological know-how and medical elements of this specialty.

Show description

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Lecture notes. / Haematology

Haematology Lecture Notes is an obtainable and concise best-selling examine consultant, outlining the body structure, pathology and therapy of the most typical blood issues. generally revised and up to date to mirror the significant advances within the realizing of the molecular biology and pathogenesis of haematological issues, it presents the center wisdom required through all clinical scholars and junior medical professionals.

Extra info for Lecture notes. / Haematology

Sample text

Fava beans contain two β-glycosides, vicine and convicine, which generate free radicals and consequently oxidize GSH and other red cell constituents. 33 Although the majority of patients with G6PD deficiency have episodic haemolytic episodes, some patients with severe enzyme defects have a more chronic haemolytic picture, with oxidative exacerbations. In these patients, the chronic haemolysis is principally extravascular. A further possible presentation of G6PD deficiency is in infancy, with hyperbilirubinaemia.

The cytopenias found in patients with enlarged spleens are also partly caused by increased pooling of blood cells within the spleen and an increased plasma volume; the magnitude of both these effects is proportioned to spleen size. In some haematological diseases in which anaemia is caused by a congenital or acquired defect of the red cell or impaired red cell formation, hypersplenism may have a role in worsening the anaemia, and splenectomy may be needed to address the effect. 4 Disorders of globin synthesis Learning objectives ✓ To understand the normal structure and function of haemoglobin ✓ To understand how the globin components of haemoglobin change ✓ ✓ ✓ ✓ ✓ ✓ ✓ during development, and postnatally To understand the mechanisms by which the thalassaemias arise To appreciate the clinical presentations and complications of thalassaemia To appreciate the contribution of haemolysis and ineffective erythropoiesis to the pathophysiology of thalassaemia To understand the pathophysiology of sickle cell anaemia To be able to describe the clinical presentation and complications of sickle cell anaemia To understand the role of haemoglobin electrophoresis and high performance liquid chromatography in the investigation of globin disorders To appreciate the many other haemoglobin variants associated with disease Normal structure and function of haemoglobin Haemoglobin is critical to the normal function of the red cell, the fundamental role of which is the transport of oxygen from the lungs to the tissues.

By contrast, in intravascular haemoysis, the red cells are caused to rupture and release their haemoglobin (Hb) directly into the circulation. The Haematology Lecture Notes, Ninth edition. R. C. Hughes-Jones, D. Hay and D. Keeling. © 2013 John Wiley & Sons, Ltd. Published 2013 by John Wiley & Sons, Ltd. Haemolytic anaemias intra/extravascular site of red cell destruction may give clues to the underlying aetiology of the haemolysis. Laboratory evidence of haemolysis Both biochemical and haematological laboratory investigations can provide evidence of haemolysis.

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