Diverse Effects of Hypoxia on Tumor Progression (Current by M. Celeste Simon

By M. Celeste Simon

Hypoxia, outlined as decreased oxygen stress, is a typical physiological phenomenon in either common embryonic improvement and malignancy development. even if critical hypoxia is mostly poisonous for either common tissue and tumors, neoplastic cells steadily adapt to lengthy hypoxia although extra genetic and genomic alterations with a web end result that hypoxia promotes tumor development and healing resistance. Hypoxia promotes melanoma development through regulating quite a few features of melanoma biology, together with radiotherapy resistance, metabolism, angiogenesis and invasion/migration

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By M. Celeste Simon

Hypoxia, outlined as decreased oxygen stress, is a typical physiological phenomenon in either common embryonic improvement and malignancy development. even if critical hypoxia is mostly poisonous for either common tissue and tumors, neoplastic cells steadily adapt to lengthy hypoxia although extra genetic and genomic alterations with a web end result that hypoxia promotes tumor development and healing resistance. Hypoxia promotes melanoma development through regulating quite a few features of melanoma biology, together with radiotherapy resistance, metabolism, angiogenesis and invasion/migration

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Additional info for Diverse Effects of Hypoxia on Tumor Progression (Current Topics in Microbiology and Immunology, Vol. 345)

Sample text

3 Contribution of the Adult Bone Marrow to the Tumor Stroma . . . . . . . . . . . 34 3 Carcinoma Associated Fibroblasts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Definition of CAFs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Tissue Origin of CAFs and Molecular Mechanisms that Control Their Differentiation and Activity . . . . . . . . . . . . . . . .

2 CAFs and Hypoxia: A Working Hypothesis . . . . . . . . . . . . . . . . . . . . . 39 5 Future Perspectives . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 Abstract In recent years, a variety of experimental evidence has convincingly shown that progression of malignant tumors does not depend exclusively on cellautonomous properties of the cancer cells, but can also be influenced by the tumor stroma.

2 Fibrocyte Progenitor Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Contribution of the Adult Bone Marrow to the Tumor Stroma . . . . . . . . . . . 34 3 Carcinoma Associated Fibroblasts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Definition of CAFs . . . . . . . . . . . . . . . . . . .

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