Current Topics in Microbiology and Immunology / Ergebnisse by A. Globerson (auth.), W. Arber, W. Henle, P. H.

By A. Globerson (auth.), W. Arber, W. Henle, P. H. Hofschneider, J. H. Humphrey, N. K. Jerne, P. Koldovský, H. Koprowski, O. Maaløe, R. Rott, H. G. Schweiger, M. Sela, L. Syruček, P. K. Vogt (eds.)

Expression of an immune reaction is the internet results of complicated synergis­ tic and hostile actions played through numerous mobile varieties. It comprises macrophages, T and B populations that could have interaction in functionality of a reaction, and suppressor cells interfering with it. as a result, a scarcity of res­ ponse won't unavoidably point out absence of immunocompetent cells, yet really nonexpression of competence. therefore, one may still examine attainable occasions, that are in no way jointly specific, to account for immuno­ good judgment unresponsiveness: (a) a number of of the mobile populations composing the synergistic unit is absent or immature, and (b) an hostile unit which interferes with the reaction is dominating. In view of this, an method of improvement of immune reactivity necessitates parallel surveys of improvement of cells with the capability to accomplish, in addition to of cells which could suppress the reaction. category of a few of the phone forms has been dependent to this point on their phenotypic homes (e. g. , membrane antigen markers, cellphone receptors, seasoned­ duction and secretion of immunoglobulins, and so on. ). Genotypically, T and B cells may possibly characterize both separate, self sustaining cellphone traces, or various levels of improvement in the similar mobile lineage.

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By A. Globerson (auth.), W. Arber, W. Henle, P. H. Hofschneider, J. H. Humphrey, N. K. Jerne, P. Koldovský, H. Koprowski, O. Maaløe, R. Rott, H. G. Schweiger, M. Sela, L. Syruček, P. K. Vogt (eds.)

Expression of an immune reaction is the internet results of complicated synergis­ tic and hostile actions played through numerous mobile varieties. It comprises macrophages, T and B populations that could have interaction in functionality of a reaction, and suppressor cells interfering with it. as a result, a scarcity of res­ ponse won't unavoidably point out absence of immunocompetent cells, yet really nonexpression of competence. therefore, one may still examine attainable occasions, that are in no way jointly specific, to account for immuno­ good judgment unresponsiveness: (a) a number of of the mobile populations composing the synergistic unit is absent or immature, and (b) an hostile unit which interferes with the reaction is dominating. In view of this, an method of improvement of immune reactivity necessitates parallel surveys of improvement of cells with the capability to accomplish, in addition to of cells which could suppress the reaction. category of a few of the phone forms has been dependent to this point on their phenotypic homes (e. g. , membrane antigen markers, cellphone receptors, seasoned­ duction and secretion of immunoglobulins, and so on. ). Genotypically, T and B cells may possibly characterize both separate, self sustaining cellphone traces, or various levels of improvement in the similar mobile lineage.

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General methods for the study of cells and serum during the immune response. The response to dinitrophenyl in mice. Clin. expo Immunol. 4, 473-487 (1969) KLINMAN, N. : The stimulation of splenic foci in vitro. J. Immunol. 106, 1338-1344 (1971) KOCH, W. : Transmission of radioisotopically labeled materials during embryonic induction in vitro. Develop. Biol. 7, 303-323 (1963) 36 A. GLOBERSON: KOLLER, P. , DAVIES, A. J. : Studies on thymus grafts in irradiated mice: repopulation of the graft. In: The Lymphocyte in Immunology and Haemopoiesis.

BUCSI, R. : Splenic determination of immunocompetence: Influence on other lymphoid organs. Cell. Immunol. 2, 627-633 (1971) BEALE, G. : The antigen system of Paramecium aurelia. Int. Rev. Cytol. : The source of leucocytes and the true function of the thymus. Anal. Anz. 18, 550-573 (1900). : Effect of adult peritoneal cells on the antibody response of newborn mice to sheep red blood cells. J. Immunol. 106,1681-1683 (1971) 30 A. : T and B lymphocytes in thymus of SJL/j mice. : Graft reaction in tissue culture.

Immune responses in vitro. 1. Culture conditions for antibody synthesis. Cell. Immunol. 3, 264-276 (1972) Development of Immune Reactivity 31 CLINE, M. , MOORE, M. A. : Embryonic origin of the mouse macrophage. Blood 39, 842-849 (1972) CLINE, M. , SUMNER, M. : Bone marrow macrophage precursors. 1. Some functional characteristics of the early cells of the mouse macrophage series. Blood 40, 62-70 (1972) COHEN, I. : Autosensitization in vitro. J. expo Med. 133, 834-845 (1971) COHEN, J. , PATTERSON, C.

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