Crush Step 1: The Ultimate USMLE Step 1 Review, 1e by Theodore X. O'Connell

By Theodore X. O'Connell

If you happen to know the entire techniques in Crush Step 1: the final word USMLE Step 1 Review, you might want to do far better than pass USMLE Step 1: you have to Crush it! Led through Theodore X. O'Connell, MD, the writer of the best-selling USMLE Step 2 Secrets and Brochert's overwhelm Step 2, this concentrated, high-yield overview of middle content material and try out prep options is the simplest USMLE Step 1 training available for this high-stakes examination. Written and reviewed via scholars, citizens, and specialists, Crush Step 1 is the source you want to rating high!

  • Focus on crucial suggestions and grasp them efficiently with up to date, easy-to-read, high-yield assurance of all the fabric validated at the exam.
  • Ensure your comprehension with USMLE Step 1 perform questions following key sections in addition to rapid-review high-yield boxes.
  • Learn how one can examine for USMLE Step 1 with a extra strategic approach via a different specialise in deciding upon and realizing query stems rather than memorizing buzz words.
  • Spend extra time learning and not more time searching because of a well-written, simply obtainable method, with lots of worthwhile lists and tables to focus on high-yield data.
  • Depend at the relevance and accuracy of the content due to oversight by means of authors who scored in the 99th percentile at the USMLE Step 1 examination and overview forums constituted of scholars, citizens, and faculty.

Show description

By Theodore X. O'Connell

If you happen to know the entire techniques in Crush Step 1: the final word USMLE Step 1 Review, you might want to do far better than pass USMLE Step 1: you have to Crush it! Led through Theodore X. O'Connell, MD, the writer of the best-selling USMLE Step 2 Secrets and Brochert's overwhelm Step 2, this concentrated, high-yield overview of middle content material and try out prep options is the simplest USMLE Step 1 training available for this high-stakes examination. Written and reviewed via scholars, citizens, and specialists, Crush Step 1 is the source you want to rating high!

  • Focus on crucial suggestions and grasp them efficiently with up to date, easy-to-read, high-yield assurance of all the fabric validated at the exam.
  • Ensure your comprehension with USMLE Step 1 perform questions following key sections in addition to rapid-review high-yield boxes.
  • Learn how one can examine for USMLE Step 1 with a extra strategic approach via a different specialise in deciding upon and realizing query stems rather than memorizing buzz words.
  • Spend extra time learning and not more time searching because of a well-written, simply obtainable method, with lots of worthwhile lists and tables to focus on high-yield data.
  • Depend at the relevance and accuracy of the content due to oversight by means of authors who scored in the 99th percentile at the USMLE Step 1 examination and overview forums constituted of scholars, citizens, and faculty.

Show description

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Extra info for Crush Step 1: The Ultimate USMLE Step 1 Review, 1e

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Xanthine oxidase converts hypoxanthine to xanthine, and then converts xanthine to uric acid. Two diseases are closely associated with degradation of purines. ❍ Gout occurs when there are high levels of uric acid in the blood (hyperuricemia), which can be caused by overproduction or underexcretion of uric acid. Monosodium urate crystals deposit in the joints, leading to inflammatory arthritis. Most patients with gout underexcrete uric acid. These patients are treated with uricosuric drugs, such as probenecid or sulfinpyrazone, which help to increase the amount of uric acid that is excreted.

Treatment of homocystinuria includes reduced intake of methionine and administration of vitamin supplements. Alkaptonuria is a deficiency of homogentisic acid oxidase causing arthritis, dark pigmented cartilage, and urine that turns dark when left standing. CHAPTER 2 ■ BIOCHEMISTRY 27 Table 2-3 Inborn Errors of Amino Acid Metabolism DISORDER Phenylketonuria Alkaptonuria Oculocutaneous albinism Homocystinuria Maple syrup urine disease DEFICIENCY GENETICS Phenylalanine hydroxylase Homogentisic acid oxidase Tyrosinase AR Cystathionine β-synthase Branched-chain β-ketoacid decarboxylase AR AR AR AR CLINICAL FEATURES Mental retardation, epilepsy, fair skin, urine has a “mousey” odor Homogentisic aciduria (dark urine), arthritis, darkly pigmented collagenous tissues Hypopigmentation, vision defects, photophobia, increased skin cancer risk Mental retardation, ectopia lentis (dislocation of lens), thrombosis, skeletal abnormalities Mental retardation, metabolic acidosis, urine has a maple syrup odor AR, autosomal recessive.

The tumorous chromaffin cells secrete large amounts of catecholamines, leading to elevated heart rate, elevated blood pressure, and sweating. Diagnosis of pheochromocytoma includes measuring plasma for catecholamines and metanephrines or urine for vanillylmandelic acid (VMA). Neuroblastomas may also produce elevated levels of catecholamines and are tested for in a similar manner. Measuring urine VMA and plasma catecholamines/ metanephrines can detect pheochromocytoma and neuroblastomas.  2-14).

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