By Anthony B. Ward, Michael P. Barnes
Botulinum pollutants now play a really major position within the administration of a wide selection of health conditions; from complications to hypersalivation, and from spasticity to sweating. during this ebook, a powerful, overseas group of specialists define the elemental neurochemistry of botulinum pollutants and chart the development of the drug from laboratory to medical institution. Then person chapters summarize their use for the most scientific symptoms within the context of alternative to be had remedies. This booklet may be of curiosity to neuroscientists and practicing clinicians operating in quite a lot of specialities, from neurology and dermatology to pediatrics, cosmetic surgery and rehabilitation drugs.
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Additional resources for Clinical Uses of Botulinum Toxins
10. , De Grandis, D. and Montecucco, C. (2001). Treatment of Frey Syndrome with botulinum toxin type F. Arch. Otolaryngol. , 127, 339À40. 11. Sheean, G. L. and Lees, A. J. (1995). Botulinum toxin F in the treatment of torticillis clinically resistant to botulinum toxin A. J. Neurol. Neurosurg. Psychiatry, 59, 601À7. 12. Greene, P. E. and Fahn, S. (1996). Response to botulinum toxin F in seronegative botulinum toxin A-resistant patients. Movement Disorders, 14, 181À4. 13. , Hambleton, P. and Shone, C.
Signals transmitted from the periphery through synapses in the spinal cord to the brain lead to the sensation of pain. Severe chronic and neurogenic pain are poorly treated by existing drugs such as 39 Botulinum toxin: from menace to medicine morphine, for which tolerance can quickly develop; there is an urgent need for novel and effective pain therapies. While the native botulinum neurotoxins are potent inhibitors of neurotransmission from pain-conducting neurons52, they are not selective for these neurons and block transmission from motor neurons even more efficiently53.
Inactive botulinum neurotoxins have also been proposed as carriers for oral vaccines by virtue of their ability to cross gut and airway epithelial layers61,62. While the clostridial neurotoxins have significant potential for the delivery of therapeutics to the nervous system, a programme of work with a clear clinical target has yet to emerge. REFERENCES 1. Scott, A. , Rosenbaum, A. L. and Collins, C. C. (1973). Pharmaceutical weakening of extraocular muscles. Invest. , 12, 924À7. 2. Scott, A. B.