By Terry W. Campbell, Krystan Grant
Clinical circumstances in Avian and unique Animal Hematology and Cytology demonstrates the way to use hemic cytology and cytodiagnosis as a part of the evaluate of an unique animal sufferer, taking the reader via approximately a hundred real scientific circumstances. With a spotlight on cytological interpretation, the hands-on, useful method allows studying, instructing, and comprehension. Well illustrated all through, Clinical situations in Avian and unique Animal Hematology and Cytology is a beneficial consultant for exotics veterinarians, zoo and aquarium veterinarians, and veterinary hematologists.
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Extra info for Clinical Cases in Avian and Exotic Animal Hematology and Cytology
II. THROMBOCYTOPENIA Thrombocytopenia, using the standard definition of a platelet count of less than 150 · 109/L, is the most common clinical effect of HIT, occurring in 85–90% of patients (Warkentin, 1998a). An even higher proportion develops “thrombocytopenia” if a definition appropriate for the clinical situation is used. A. , 1973). King and Kelton (1984) noted that thrombocytopenia occurred between days 6 and 15 for more than 90% of patients in whom HIT occurred during their first exposure to heparin.
Heparin treatment was complicated by thrombocytopenia and progression of venous thrombosis. Professor Job Harenberg of Heidelberg University, who had performed phase I evaluations of the experimental glycosaminoglycan anticoagulant danaparoid, requested this agent from the manufacturer (NV Organon, The Netherlands). , 1983, 1997). Over the next 6 yr, this patient developed recurrent thromboembolic events, and was successfully treated each time with danaparoid. This favorable experience led to a named-patient, compassionate-release program ending in March 1997, during which time, over 750 patients were treated with this agent.
Its strong association with venous and arterial thrombosis represents a striking paradox. However, thrombocytopenia itself is common in clinical medicine. Furthermore, heparin is usually given to patients who either have thrombosis, or who are judged to be at high risk for thrombosis. Thus, thrombocytopenia with or without thrombosis during heparin treatment does not necessarily indicate a diagnosis of HIT. Indeed, several disorders can closely resemble HIT (see Chapter 11). On the other hand, HIT is associated with a wide spectrum of unusual thrombotic and other complications (Table 1).