Chronic Lymphocytic Leukemia by Federico Caligaris-Cappio, Riccardo Dalla Favera

By Federico Caligaris-Cappio, Riccardo Dalla Favera

Chronic lymphocytic leukaemia (CLL) is the commonest leukaemia within the Western global. it's also the prototype of B-cell power lymphoid malignancies and in their ramifications in the fields of hematology, immunology and oncology. For a long time the Cinderella of lymphoid malignancies CLL has now turn into the point of interest of significant curiosity and more and more investigators from diversified components, together with genetics, molecular biology, easy and utilized immunology have gotten actively engaged within the research of CLL. Clinicians are contemplating CLL as a really attention-grabbing aim of many tasks which objective at translating the hot and interesting advancements of uncomplicated technology into powerful new techniques to the sufferer.

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By Federico Caligaris-Cappio, Riccardo Dalla Favera

Chronic lymphocytic leukaemia (CLL) is the commonest leukaemia within the Western global. it's also the prototype of B-cell power lymphoid malignancies and in their ramifications in the fields of hematology, immunology and oncology. For a long time the Cinderella of lymphoid malignancies CLL has now turn into the point of interest of significant curiosity and more and more investigators from diversified components, together with genetics, molecular biology, easy and utilized immunology have gotten actively engaged within the research of CLL. Clinicians are contemplating CLL as a really attention-grabbing aim of many tasks which objective at translating the hot and interesting advancements of uncomplicated technology into powerful new techniques to the sufferer.

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Cancer Genet Cytogenet 129:138–144 Schroeder HW Jr, Dighiero G (1994) The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire. Immunol Today 15:288–294 48 U. Klein · R. Dalla-Favera Shipp MA, Ross KN, Tamayo P, Weng AP, Kutok JL, Aguiar RC, Gaasenbeek M, Angelo M, Reich M, Pinkus GS, Ray TS, Koval MA, Last KW, Norton A, Lister TA, Mesirov J, Neuberg DS, Lander ES, Aster JC, Golub TR (2002) Diffuse large Bcell lymphoma outcome prediction by gene-expression profiling and supervised machine learning.

2004; Kolar and Capra 2004), and subgroups of B-CLL show similar CDRIII regions of light and/or heavy chains (Widhopf et al. 2004). These observations may suggest that the binding of specific antigen receptors to particular foreign antigens or autoantigens provides a continuous stimulatory signal through the BCR that keeps the B-CLL precursor in cell cycle for long periods of time and eventually allows for the acquisition of genomic aberrations. Finally, we would like to introduce the possibility that B-CLL and hairy cell leukemia have a similar cell of origin.

Mol Cancer Res 1:346–361 Kantor AB, Stall AM, Adams S, Watanabe K, Herzenberg LA (1995) De novo development and self-replenishment of B cells. Int Immunol 7:55–68 Kindler V, Zubler RH (1997) Memory, but not naive, peripheral blood B lymphocytes differentiate into Ig-secreting cells after CD40 ligation and costimulation with IL-4 and the differentiation factors IL-2, IL-10, and IL-3. J Immunol 159:2085–2090 Kipps TJ (1998) Chronic lymphocytic leukemia. Curr Opin Hematol 5:244–253 Klein U, Rajewsky K, Küppers R (1998) Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells.

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