Cellular Peptide Hormone Synthesis and Secretory Pathways by Jan Fahrenkrug (auth.), Jens F. Rehfeld, Jens R. Bundgaard

By Jan Fahrenkrug (auth.), Jens F. Rehfeld, Jens R. Bundgaard (eds.)

The function of the current quantity is to demonstrate the fashionable organic thought of uncomplicated endocrinology in a single unmarried publication. It first describes normal matters akin to maturation of secretory granules within the cells, the jobs of the chaperonic granins, and cell-specific prohormone processing. to that end, the explicit a part of the e-book illustrates the hot endocrine biology, utilizing as examples a wide number of person peptide structures: ACTH, Neurotensin and Neuromedines, Natriuretic Peptides, Glucagon and Glucagon-like peptides, Somatostatin, Ghrelin, Gastrin and VIP (Vasoactive Intestinal Polypeptide).

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By Jan Fahrenkrug (auth.), Jens F. Rehfeld, Jens R. Bundgaard (eds.)

The function of the current quantity is to demonstrate the fashionable organic thought of uncomplicated endocrinology in a single unmarried publication. It first describes normal matters akin to maturation of secretory granules within the cells, the jobs of the chaperonic granins, and cell-specific prohormone processing. to that end, the explicit a part of the e-book illustrates the hot endocrine biology, utilizing as examples a wide number of person peptide structures: ACTH, Neurotensin and Neuromedines, Natriuretic Peptides, Glucagon and Glucagon-like peptides, Somatostatin, Ghrelin, Gastrin and VIP (Vasoactive Intestinal Polypeptide).

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Notably CgA and SgII appear to be involved in mechanisms of disease, such as hypertension, heart failure, and inflammatory syndromes (Taupenot et al. 2003; Ceconi et al. 2002; Ferrero et al. 2004; Di Comite et Chromogranins A and B and Secretogranin II as Prohormones for Regulatory Peptides 23 al. 2009; Zhang et al. 2008; 2009a) Although a coherent picture of the physiological impact of these granin-derived peptides is yet to be drawn, the available information lends substantial support for significant contributions of peptides derived from CgA, CgB, and SgII as modulators of normal and pathophysiological functions.

2006, 2008; Cappello et al. 2007; Gallo et al. 2007) but also of CAT (Mazza et al. 2008; Angelone et al. 2008). The N-terminal peptides CgA1–76 and CgA1–113 obtained from the retrogradely stimulated bovine adrenal medulla (Helle et al.  1a), as a reflection of their suppressive effects in precontracted isolated human conduit vessels (Aardal and Helle 1992; Aardal et al. 1993). VS-I is a natural cleavage product of CgA in man and larger mammals (Stridsberg et al. 2000) but not in the rat (Glattard et al.

1986), the bovine parathyroid cells for CgB1–41 (Russell et al. 1994) and the rat striatum for SN (Saria et al. 1993). During the last decade, the spectrum of targets has increased exponentially, notably for the CgA-derived peptides and for SN. There is also accumulating support for the vascular endothelium as a pivotal target not only for the CgA peptide VS-I but also for SN. In the following, the target systems will be discussed in relation to functions modulated by one or more of the granin peptides.

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