By Paul S. Giacomini
This handbookis a suite of scientific narratives that underscore the heterogeneous and unpredictable presentation of a number of sclerosis (MS) and provides real-world medical context to contemporary drug advancements. This available and concise e-book is meant for use via a variety of doctors, from professional neurologists to scientific trainees with an curiosity in neurology. a fantastic medical source, Case reviews in a number of Sclerosis offers an evidence-based dialogue of every case, with an objective to reinforce potent analysis and remedy of sufferers with MS and MS-related conditions.
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Extra info for Case Studies in Multiple Sclerosis
She had brisk (3+) reflexes in her right arm and leg, and left-sided reflexes were normal. The right plantar response was upgoing. She had difficulty walking without assistance and had a clear hemiparetic gait. The remaining neurological examination was intact. S. 1007/978-3-319-31190-6_4 27 28 • C A S E S TU D I E S I N M U LT IP LE S CLE R O S IS Investigations Blood tests and a urine culture were obtained in the emergency department. The results showed no signs of an acute infection. She underwent a brain MRI that showed the presence of more than ten hyperintense T2-weighted imaging lesions that were all compatible with demyelination.
ARR: •• 53% reduction 2. Confirmed disability progression at 2 years: •• 38% reduction Lymphopenia Secondary autoimmunity (thyroid disorders, ITP, nephropathies) Cytopenias Infections •• cardiac arrythmias •• hypotension •• hypertension •• •• •• •• •• •• •• headache rash fever urticaria flushing nausea chills Serious infusion reactions: Adverse events Infusion-associated reactions: Side effects (most common) Compared to placebo : 2. Confirmed disability progression: •• 71% reduction1 •• 42% reduction3 1.
There are a variety of reasons for medication nonadherence. A common cause is a perceived lack of efficacy . Many patients perceive that treatment is ineffective when their current symptoms do not resolve. Pseudorelapses can also contribute to this perception. Since the currently available therapies are not cures and are only intended to prevent additional disease activity, it is important to set reasonable expectations when discussing treatment options. All medications have adverse effects.