By Matt Kalaycio
Interesting new "biologic" treatments for treating leukemia are showing so quickly that clinicians frequently locate it tricky to make knowledgeable judgements approximately their use whilst making sufferer remedy judgements. Biologic remedy of Leukemia summarizes and reports the entire to be had information touching on those state of the art biologic treatments in order that practising clinicians could make the proper patient-care offerings. right here the busy medical professional will locate in a single handy position an important details at the makes use of and obstacles of the main biologic cures for leukemia, the several biologic recommendations for its remedy, the administration of sufferers being taken care of with such biologic brokers, and the present and destiny function of rising biologic brokers.
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Extra resources for Biologic Therapy of Leukemia (Contemporary Hematology)
Johnson B, Truitt R. Delayed infusion of immunocompetent donor cells after bone marrow transplantation breaks graft-versus-host tolerance and allows for persistent antileukemic reactivity without severe graft-versus-host disease. Blood 1995;85:3302–3312. 27. Nieda M, Nicol A, Kikuchi A, et al. Dendritic cells stimulate the expansion of bcr-abl specific CD8+ T cells with cytotoxic activity against leukemic cells from patients with chronic myeloid leukemia. Blood 1998;91:977–983. 28. Krijanovski O, Hill G, Cooke K, et al.
However, six patients (12%) experienced severe toxicity manifested as fever, chills, hypoxia, and hypotension. Importantly, only one of these patients had B-CLL. The other five patients had other lymphoid leukemias, such as mantle cell leukemia. Thus, severe first-dose toxicity was noted in 2% of patients with B-CLL, regardless of white blood cell count and 50% of patients with other lymphoid leukemias. There was no dose-limiting toxicity to subsequent higher doses of rituximab. Overall, 40% of patients achieved a partial response (28).
D. Anderson experience with mini-transplantations was recently reported (61). Seventy-eight patients received fludarabine and melphalan as a preparative regimen, and eight received cladribine and melphalan. The median patient age was 52 yr (22–70 yr range). Most patients had advanced hematologic malignancies. The median percentage of donor cells at 1 mo in 75 patients was 100%. 29, respectively. Disease-free survival at 1 yr was 57% for patients in first remission and 49% for patients with more advanced disease.