By Lesley-Ann Giddings, David J. Newman
This SpringerBrief sheds new mild on bioactive fabrics from marine extremophiles. It offers with all elements of the chemicals produced by means of organisms residing below severe stipulations which may have strength as medicines or bring about novel medicinal drugs for human use.
Read or Download Bioactive Compounds from Marine Extremophiles (SpringerBriefs in Microbiology / Extremophilic Bacteria) PDF
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Extra info for Bioactive Compounds from Marine Extremophiles (SpringerBriefs in Microbiology / Extremophilic Bacteria)
2008). A mixed polyketide/nonribosomal peptide containing a nitro-group was reported by Nereus Pharmaceuticals, Inc. This antibiotic was produced by Streptomyces nodosus NPS007994 isolated from marine sediment collected in a narrow gorge north of Scripps Institution of Oceanography in La Jolla, CA, USA (Manam et al. 2005). The metabolite was determined to be the nitro-tetraene spiro-β-lactone– lactam lajollamycin 125 (Fig. 7), which exhibited antimicrobial activity against drug-sensitive and drug-resistant Gram-positive as well as Gram-negative eubacteria.
Splenocin F; R = CH2(CH2)3CH3 175. Splenocin G; R = CH2(CH2)4CH3 176. Splenocin H; R = CH2CH(CH3)(CH2)3CH3 177. Splenocin I; R = CH2Ph 169. Splenocin A; R = CH3 170. Splenocin B; R = CH(CH3)2 171. Splenocin C; R = CH(CH3)CH2CH3 O O O C7 O 168. Arenamide C O O O O O OH C7 O 178. Splenocin J O HO HO O 179. Eicosapentaenoic acid 182. Docasahexaenoic acid O O HO 180. α-Linolenoic acid O 183. Ethyl eicosapentaenoic acid O HO O 181. Docasapentaenoic acid (Clupanodonic acid) HO 184. Moroctic acid Fig.
As the focus of natural products isolation is increasingly shifting more in the direction of marine environments and new fermentation conditions are being developed to mimic marine habitats, this list will increase signiﬁcantly within the next few years. References Asolkar et al. (2006) Wang et al. (2006) Cytotoxic Cytotoxic Cytotoxic Cytotoxic Cytotoxic Cytotoxic; antifungal Cytotoxic Cytotoxic (inhibitor of 12-Otetradecanoylphorbol-13-acetate (TPA)-induced activation of the Epstein–Bar virus early antigen) Chinikomycins A and B (14–15) Gutingimycin 16 Mechercharstatins A–B (17–18) Urukthapelstatin A 19 Piperazimycins A–C (20–22) Daryamides A–C (23–25) (2E,4E)-7-Methylocta-2,4-dienoic acid amide 26 3-(4′-Hydroxyphenyl)-4-phenylpyrrole-2,5-dicarboxylic acid (HPPD-1) 27 Asolkar et al.