By Lesley-Ann Giddings, David J. Newman
This SpringerBrief sheds new mild on bioactive fabrics from marine extremophiles. It bargains with all facets of the chemicals produced by way of organisms dwelling lower than severe stipulations that could have strength as medicines or result in novel medications for human use.
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Additional info for Bioactive Compounds from Marine Extremophiles
Example text
Yohimbine, vancomycin, and paclitaxel) have been used to develop focused libraries by performing parallel syntheses via methods such as solid-phase synthesis. The structural diversity of marine natural products provides an abundance of unique pharmacophores that can be used in the drug development process. Not only can new drug leads to be identified but enzymatic mechanisms of action can be further elucidated; hence, the goal of several research groups has been to screen extracts from marine-derived microorganisms to find selective inhibitors.
Eicosapentaenoic acid 182. Docasahexaenoic acid O O HO 180. α-Linolenoic acid O 183. Ethyl eicosapentaenoic acid O HO O 181. Docasapentaenoic acid (Clupanodonic acid) HO 184. Moroctic acid Fig. 9 Structures 159–184 structural class of myxobacterial natural products with polyunsaturated carbon chains and aromatic rings. Phenylnannolones A 159 and C 161 have a rare ethylsubstituted polyene chain at C8 linked to a pyrone moiety and phenyl ring. 2 Culturable Marine Microbes 37 In addition, phenylnannolone C 161 possesses an additional hydroxyl group at C15, whereas phenylnannolone B 160 lacks substituents at C8 and C15.
1986). By screening 3,000 strains of marine microorganisms, the serine protease inhibitors marinostatins B-1 (152) (Fig. 8), B-2, C-1, and C-2 were isolated from the eubacterium Alteromonas sp. from nearshore seawater of Japan. The marinostatins are low molecular weight 12 (152 and marinostatin C-1)- and 14-residue (marinostatins B-2 and C-2) peptides consisting of the amino acids, such as aspartic acid, threonine, serine, glutamic acid, proline, alanine, methionine, tyrosine, phenylalanine, and arginine.