By Thomas Ming Swi Chang
It is a entire and primary classification overview of approximately all very important and basic advancements of artifiical cells by way of the nestor of this department in utilized biomedial technology himself. This "bible" is vital studying for either newbies and the skilled specialist. Chang wrote a great and stimulating assessment over 50 years of man-made cellphone learn and improvement and functions.
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Additional info for Artificial Cells: Biotechnology, Nanomedicine, Regenerative Medicine, Blood Substitutes, Bioencapsulation, Cell/Stem Cell Therapy (Regenerative Medicine, Artificial Cells and Nanomedicine)
Ch02 FA April 2, 2007 12:8 SPI-B446 Artiﬁcial Cells: Biotechnology, Nanotechnology, Blood Substitutes, Regenerative... 2. 15 Nanotechnology and Nanobiotechnology There is much recent interest in nanotechnology. Nanotechnology is a large and complex area that embraces many diverse approaches. One of these is to make the original artiﬁcial cells smaller using the same basic principles and method. This includes biodegradable nanoparticles, nanospheres and nanocapsules. Examples include nano artiﬁcial red blood cells with lipid membrane (Djordjevich and Miller, 1980) or biodegradable polymeric membranes nano artiﬁcial red blood cells (WP Yu and Chang, 1994) (Fig.
The result was hemoperfusion based on artiﬁcial cells, being carried out routinely around the world for the treatment of suicidal and accidental uses of medications in adult and pediatric patients. In the meantime, I was completing an invited monograph for Charles C. Thomas Publisher and it contained a detailed description of methods. On becoming a tenured full professor in 1972, I immediately had this published (Chang 1972a). The advantage of having “tenure” is that it enabled me to safely use the title “Artiﬁcial cells” instead of “Semipermeable microcapsules” for this monograph!
If the emulsions are made very small, then the whole submicron artiﬁcial cells can be crosslinked into PolyHb of nanodimension. Glutaraldehyde can crosslink Hb into soluble PolyHb of nanodimension (Chang, 1971b) (Fig. 2). , 2002). Oxygen carriers developed by one group are in routine clinical use in South Africa (Lok, 2001). There are also other types of Hb-based oxygen carriers that are not based on nanobiotechnology. This chapter discusses why nanobiotechnology has been used and how Hb-based oxygen carriers prepared using this approach compare with other types of Hb-based oxygen carriers.